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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but they are unusual in this malignancy when compared to other lymphoid neoplasms. CHD2
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).eighty two,eighty three Sufferers with MBL with mutated motorists have a shorter time to very first cure when compared to situations devoid of mutations. When CLL is set up, the growth dynamics of tumor cells is heterogeneous. Some individuals exhibit a logistic-like conduct during which the clone stabilizes eventually, Whilst some Other people display an exponential- like expansion sample.eighty four This exponential development, clinically outlined as “limited lymphocyte doubling time” remains thought of an adverse prognostic parameter in CLL.
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東南海・南海地震における浄水場 のリスクに関する一考察（その２） 中井 c加振振動数を変化させた実験 地震動の振動数の変化が，ろ過水濁度上昇に与え る影響を明らかにするため，入力加速度 150gal，継 続時間
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